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KMID : 1146920190490020271
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Journal of Pharmaceutical Investigation
2019 Volume.49 No. 2 p.271 ~ p.278
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Effect of surfactant on the preparation and characterization of gemcitabine-loaded particles
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Lim Ji-Ho
Na Young-Guk
Lee Hong-Ki
Kim Sung-Jin
Lee Hye-Jin
Bang Ki-Hyun
Wang Miao
Pyo Yong-Chul
Huh Hyun-Wook
Cho Cheong-Weon
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Abstract
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Gemcitabine is used in the treatment of several solid tumors as one of anticancer nucleoside analogues and is necessary to administer high doses to achieve the desired therapeutic response. However, this treatment may be related to severe side effects. For improvement of the encapsulation efficiency of gemcitabine for gemcitabine-loaded nanoparticle composed of biodegradable polymer and reducing the side effects due to the high concentration of gemcitabine, we formulated gemcitabine-loaded PLGA particles using chitosan and different type of surfactant. The gemcitabine-loaded particles were prepared using a double emulsion solvent evaporation technique. The effects of surfactants to modify the size of gemcitabine-loaded particles were different. The mean diameters of gemcitabine-loaded particles ranged from 400.8 nm to 1712.7 nm. The surface charge of gemcitabine particles was ??5.62 mV to 1.46 mV. The encapsulation efficiency of gemcitabine-loaded particles was found to be 29.56?34.38%. Interestingly, the addition of surfactant could be improved an encapsulation efficiency of gemcitabine.
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KEYWORD
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Gemcitabine, Polymeric nanoparticles, Surfactan, Encapsulation efficiency, Cytotoxicity
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